Vascular dementia

Dr Henry Knipe and Dr Jeremy Jones et al.

Vascular dementia, also known as vascular cognitive impairment, is the second most common cause of dementia after the far more common Alzheimer's disease. It is primarily seen in patients with atherosclerosis and chronic hypertension and results from the accumulation of multiple white matter or cortical infarcts, although cerebral haemorrhages can be variably included 4

It is also possible to divide vascular dementia into subtypes, although no general agreement has been reached, and there is some overlap between them 4

  1. small vessel dementia (a.k.a. Binswanger disease)
  2. cortical vascular dementia roughly equivalent to multi-infarct dementia
  3. strategic infarct dementia
  4. thalamic dementia

Incidence has been variably reported, but is strongly correlated with age, seen in only 1% of patients over the age of 55 years of age, but in over 4% of patients over 71 years of age 3. To add to the confusion, given the prevalence of Alzheimer's disease, the two are commonly seen together 4. Additionally some patients develop accelerated vascular changes due to specific underlying disease (e.g. CADASIL and Fabry disease), and thus their demographics will be quite separate from the general population. 

The presenting signs and symptoms are dependent on the areas affected and thus this is highly variable. Additionally as these infarcts are accumulated in a stepwise fashion, deterioration is similarly stepwise rather than smoothly gradual.

Generally cortical dementia and strategic infarct dementia, usually due to large vessel occlusion, have a definable time of onset and specific deficits related to the region affected 4

Subcortical or small vessel dementia in contrast has a more insidious onset and vaguer 'executive function' deficits 5. The later is therefore understandably more frequently in the differential list of other dementias. 

Both CT and MRI are able to provide evidence of ischaemic damage, however MRI is more sensitive, especially to white matter small vessel ischaemic change as well as to microhaemorrhages seen in cerebral amyloid angiopathy and chronic hypertensive encephalopathy

It is beyond the scope of this article to describe all patterns of vascular damage, and the reader is referred to: 

As befits a heterogeneous group of conditions, no single treatment exists, with the majority of effort going into treat individual risk factors for ongoing vascular damage (e.g. hypertension, smoking, hypercoagulation, atherosclerosis). 

Similarly no single prognosis can be given, being largely dependent on the underlying cause and the degree to which successful treatment can be initiated. 

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Article Information

rID: 7288
Section: Pathology
Synonyms or Alternate Spellings:
  • Multi-infarct dementia
  • Vascular cognitive impairment
  • Thalamic dementia
  • Cortical vascular dementia
  • Strategic infarct dementia

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