The venous thoracic outlet syndrome (vTOS) is the second commonest form of thoracic outlet syndrome (with neurogenic thoracic outlet syndrome being the commonest and the arterial thoracic outlet syndrome being the least common).
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Clinical presentation
It may develop suddenly, often after unusual and tiring exercise of the arms with (subclavian vein compression causes upper limb swelling and pain with resultant venous thrombosis (Paget-Schroetter syndrome).
Some can present with intermittent venous compression in the absence of thrombosis (McCleery syndrome). Patients may have swelling of the hands, fingers and arms, as well as heaviness and weakness of the neck and arms. Veins in the anterior chest wall may appear dilated.
Pathology
The typical site of subclavian vein compression is at the level of the costoclavicular space between the 1st rib, subclavius muscle, and clavicle.
Radiographic assessment
Imaging aims to assess three separate facets of this condition:
confirm the presence of stenosis/compression/obstruction
identify underlying anatomical abnormalities or variants that cause compression
characterize the vessel and identify the presence of thrombus
Plain radiograph
Chest radiography is typically performed to exclude an underlying bony abnormality.
Ultrasound
Ultrasound can both directly visualize the subclavian vein and assess flow using duplex Doppler scanning. Additionally, it is ideally suited to dynamic maneuvers (i.e. abducting the arm) and assessing for the impact that this has on flow.
CT and MRI
Both CT and MRI are able to assess regional anatomy and vascular anatomy. It is possible to also perform neutral and abducted views although this not as straightforward as with ultrasound and, in the case of CT, requires additional radiation exposure.
Features to assess include 4:
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bone and soft-tissue abnormalities
first rib callus, exostosis or osseous lesion
fibrous band
muscle insertional variation
supernumerary muscles (e.g. scalenus)
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subclavian and/or axillary vein
thrombosis
fixed venous stenosis
dynamic narrowing of the vein with abduction
enlarged collaterals
Digital subtraction venography
Digital subtraction venography is excellent at visualizing the lumen of the veins and imaging can be performed in various arm positions to demonstrate dynamic narrowing. It can also allow balloon venoplasty.