Ventral tegmental area
Last revised by Candace Makeda Moore
on 2 Oct 2019
Citation, DOI, disclosures and article data
Citation:
Moore C, Ventral tegmental area. Reference article, Radiopaedia.org (Accessed on 14 Mar 2025) https://doi.org/10.53347/rID-71349
rID:
71349
Article created:
30 Sep 2019,
Candace Makeda Moore
Disclosures:
At the time the article was created Candace Makeda Moore had no recorded disclosures.
View Candace Makeda Moore's current disclosures
Last revised:
2 Oct 2019,
Candace Makeda Moore
Disclosures:
At the time the article was last revised Candace Makeda Moore had no recorded disclosures.
View Candace Makeda Moore's current disclosures
Revisions:
1 time, by
1 contributor -
see full revision history and disclosures
The ventral tegmental area is a midline area, located medially to the substantia nigra, composed of multiple nuclei 1 in the midbrain with many dopaminergic neurons.
Historically the area was easier to delineate through gross pathology or histology than radiology. However probabilistic atlases have allowed both more precise demarcation of the area in imaging 2,3 and demonstration of variations across populations 4.
References
- 1. Song‐Lin Ding, Joshua J. Royall, Susan M. Sunkin, Lydia Ng, Benjamin A.C. Facer, Phil Lesnar, Angie Guillozet‐Bongaarts, Bergen McMurray, Aaron Szafer, Tim A. Dolbeare, Allison Stevens, Lee Tirrell, Thomas Benner, Shiella Caldejon, Rachel A. Dalley, Nick Dee, Christopher Lau, Julie Nyhus, Melissa Reding, Zackery L. Riley, David Sandman, Elaine Shen, Andre van der Kouwe, Ani Varjabedian, Michelle Write, Lilla Zollei, Chinh Dang, James A. Knowles, Christof Koch, John W. Phillips, Nenad Sestan, Paul Wohnoutka, H. Ronald Zielke, John G. Hohmann, Allan R. Jones, Amy Bernard, Michael J. Hawrylycz, Patrick R. Hof, Bruce Fischl, Ed S. Lein. Comprehensive cellular‐resolution atlas of the adult human brain. (2016) Journal of Comparative Neurology. 524 (16): 3127. doi:10.1002/cne.24080 - Pubmed
- 2. Murty VP, Shermohammed M, Smith DV, Carter RM, Huettel SA, Adcock RA. Resting state networks distinguish human ventral tegmental area from substantia nigra. (2014) NeuroImage. 100: 580-9. doi:10.1016/j.neuroimage.2014.06.047 - Pubmed
- 3. Wolfgang M. Pauli, Amanda N. Nili, J. Michael Tyszka. A high-resolution probabilistic in vivo atlas of human subcortical brain nuclei. (2018) Scientific Data. 5: 180063. doi:10.1038/sdata.2018.63 - Pubmed
- 4. Nakamura, Yuko, Okada, Naohiro, Kunimatsu, Akira, Kasai, Kiyoto, Koike, Shinsuke. Anatomical Templates of the Midbrain Ventral Tegmental Area and Substantia Nigra for Asian Populations. (2019) Frontiers in Psychiatry. 9: 383. doi:10.3389/fpsyt.2018.00383 - Pubmed
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