Citation, DOI, disclosures and article data
At the time the article was created Jeremy Jones had no recorded disclosures.View Jeremy Jones's current disclosures
At the time the article was last revised Sajanakan Sriselvakumar had no financial relationships to ineligible companies to disclose.View Sajanakan Sriselvakumar's current disclosures
The ventricular system in the brain is a series of interconnecting spaces and channels within the brain composed of cerebrospinal fluid (CSF). CSF is produced by ependymal cells which line the ventricles. They are continuous with the central canal. Ventricles contain around 20% of the total average adult CSF volume, around 20-25 mL.
The ventricular system consists of:
The interconnections between the ventricles occur through the following:
interventricular foramen (of Monro): lateral to third
cerebral aqueduct (of Sylvius): third to fourth
Major CSF production comes from choroid plexus found in the lateral, third and fourth ventricles of the brain which are highly vascularized epithelial tissue masses 3. Notably, choroid plexus is not found in the frontal or occipital horns of lateral ventricles, nor in the cerebral aqueduct.
A single cavity, or hollow of the neural tube, serves as the foundation for the ventricular system. Around the fourth week of gestation, the neural tube begins to develop. The neural cavity and amniotic cavity are then separable after the spinal neurocele closes.
From the cephalic to the caudal end, three dilatations are formed: the prosencephalon (forebrain), mesencephalon (midbrain), and rhombencephalon (hindbrain).
lateral ventricles develop from the telencephalic cavity.
third ventricle develops from the diencephalic cavity.
cerebral aqueduct develops from the restricted mesencephalic cavity, while the fourth ventricle is formed from the rhombencephalic cavity.
- 1. Stranding S. Gray's anatomy. Churchill Livingstone. (2005) ISBN:0443071683. Read it at Google Books - Find it at Amazon
- 2. Ross LMMP. Atlas of anatomy. George Thieme Verlag. (2007) ISBN:3131421215. Read it at Google Books - Find it at Amazon
- 3. Liddelow SA. Development of the choroid plexus and blood-CSF barrier. Front Neurosci. 2015 Mar 3;9:32. doi: 10.3389/fnins.2015.00032. PMID: 25784848; PMCID: PMC4347429.