Vigabatrin-associated toxicity is a potential neurological complication in patients treated with vigabatrin, an antiseizure medication whose mechanism of action includes GABA levels retention at the level of synapses in the brain. It is primarily used as a treatment of focal seizures and infantile spasm disorders. The potential for brain abnormalities to develop during treatment is well recognized 1.
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Clinical presentation
Patients with vigabatrin-associated toxicity typically experience visual disturbances.
Radiographic features
MRI
Hyperintense signal on T2, FLAIR, and DWI sequences are present in the basal ganglia, thalamus, and brainstem 1,2.
Treatment and prognosis
These changes are resolved upon the cessation of therapy 2.
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