Vitamin B6

Dr Dan J Bell and Dr Craig Hacking et al.

Vitamin B6 is a group of water-soluble vitamins that are derivatives of pyridine, namely pyridoxine, pyridoxal and pyridoxamine. All three form part of the coenzyme pyridoxal 5'-phosphate (PLP) which is involved in many cellular reactions including the synthesis of several amino acids and the metabolism of glucose and lipids.

The anti-tubercular drug isoniazid is an inactive derivative of pyridoxal phosphate, hence vitamin B6 needs to be co-administered in patients on isoniazid.

Related pathology

  • deficiency is rare, seen in alcoholics, women on the oral contraceptive pill (OCP) and neonates fed on B6-deficient formula
  • toxicity may produce neurological symptoms

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Article information

rID: 50107
Section: Pathology
Synonyms or Alternate Spellings:
  • Pyridoxamine
  • Pyridoxal
  • Pyridoxine

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