Vitamin B6

Dr Craig Hacking et al.

Vitamin B6 is a group water soluble vitamins that are deratives of pyridine, namely pyridoxine, pyridoxal and pyridoxamine. All three form part of the coenzyme pyridoxal 5'-phosphate (PLP) which is involved many cellular reaction including the synthesis of several amino acids and the metabolism of glucose and lipids.

The anti-tubercular drug isoniazid is a inactive derivative of pyridoxal phosphate, hence vitamine B6 needs to be co-administed in patients on isoniazid.

Related pathology

  • deficiency is rare, seen in alcoholics, women on the OCP and neonates fed on B6-deficient formula
  • toxicity may produce neurological symptoms

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Article information

rID: 50107
Section: Pathology
Synonyms or Alternate Spellings:
  • pyridoxine
  • pyridoxal
  • pyridoxamine

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