Vitamin B6 is a group water soluble vitamins that are deratives of pyridine, namely pyridoxine, pyridoxal and pyridoxamine. All three form part of the coenzyme pyridoxal 5'-phosphate (PLP) which is involved many cellular reaction including the synthesis of several amino acids and the metabolism of glucose and lipids.
The anti-tubercular drug isoniazid is a inactive derivative of pyridoxal phosphate, hence vitamine B6 needs to be co-administed in patients on isoniazid.
- deficiency is rare, seen in alcoholics, women on the OCP and neonates fed on B6-deficient formula
- toxicity may produce neurological symptoms
- 1. Pamela C. Champe, Richard A. Harvey (Ph. D.), Denise R. Ferrier. Biochemistry. ISBN: 0781769604