Vitamin B6 is a group of water-soluble vitamins that are derivatives of pyridine, namely pyridoxine, pyridoxal and pyridoxamine. All three form part of the coenzyme pyridoxal 5'-phosphate (PLP) which is involved in many cellular reactions including the synthesis of several amino acids and the metabolism of glucose and lipids.
The anti-tubercular drug isoniazid is an inactive derivative of pyridoxal phosphate, hence vitamin B6 needs to be co-administered in patients on isoniazid.
- deficiency is rare, seen in alcoholics, women on the oral contraceptive pill (OCP) and neonates fed on B6-deficient formula
- toxicity may produce neurological symptoms
- 1. Pamela C. Champe, Richard A. Harvey (Ph. D.), Denise R. Ferrier. Biochemistry. ISBN: 0781769604
- tumour markers