Vitamin B6 excess (hypervitaminosis B6) is caused by excessive consumption of supplemental pyridoxine, which is used as a therapeutic agent for several conditions.
Epidemiology
This hypervitaminosis is typically seen in those taking pyridoxine as prescription medication; it remains in use for a range of conditions, including isoniazid-related neuropathy, carpal tunnel impingement syndrome, pregnancy related nausea and vomiting, in restoration of cognitive function, mushroom poisoning, and some rare genetic disorders 2. However, vitamin B6 may also be inadvertently consumed in excess in those taking multivitamin or magnesium supplements, or consuming energy drinks 3.
Clinical presentation
The classic presentation of pyridoxine chronic high dosing is with a sensory-predominant peripheral neuropathy, which in several published case reports can been so severe as to impair ambulation. The other sequela reported is a dermatosis. Other putative toxicity remains contentious.
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