Vitamin B6 excess

Dr Daniel J Bell et al.

Vitamin B6 excess (hypervitaminosis B6) is caused by excessive consumption of supplemental pyridoxine, which is used as a therapeutic agent for several conditions. 


This hypervitaminosis is almost exclusively seen in those taking pyridoxine as prescription medication, it remains in use for a range of conditions, including isoniazid-related neuropathy, mushroom poisoning, and some rare genetic disorders.

Clinical presentation

The classic presentation of pyridoxine chronic high dosing is with a sensory neuropathy, which in several published case reports has been so severe as to impair ambulation. The other sequela reported is a dermatosis. Other putative toxicity remains contentious. 


Article information

rID: 64161
Synonyms or Alternate Spellings:
  • Vitamin B6 toxicity
  • Hypervitaminosis B6

Support Radiopaedia and see fewer ads

Updating… Please wait.

 Unable to process the form. Check for errors and try again.

 Thank you for updating your details.