Vitamin B6 excess
Citation, DOI & article data
Vitamin B6 excess (hypervitaminosis B6) is caused by excessive consumption of supplemental pyridoxine, which is used as a therapeutic agent for several conditions.
This hypervitaminosis is almost exclusively seen in those taking pyridoxine as prescription medication, it remains in use for a range of conditions, including isoniazid-related neuropathy, carpal tunnel impingement syndrome, pregnancy related nausea and vomiting, in restoration of cognitive function, mushroom poisoning, and some rare genetic disorders 2.
The classic presentation of pyridoxine chronic high dosing is with a sensory neuropathy, which in several published case reports has been so severe as to impair ambulation. The other sequela reported is a dermatosis. Other putative toxicity remains contentious.
- 1. Institute of Medicine, Food and Nutrition Board, A Report of the Standing Committee on the Scientific Evaluation of Dietary Reference Intakes and its Panel on Folate, Other B Vitamins, and Choline and Subcommittee on Upper Reference Levels of Nutrients. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline. (2000) ISBN: 9780309132695
- 2. Barak N, Barak HD, Barak SB, Barak. [Vitamin B6 (Pyridoxine)--excessive dosage in food supplements and OTC medications]. (2004) Harefuah. doi: - Pubmed