Vitamin K

Dr Dan J Bell and Dr Craig Hacking et al.

Vitamin K (phylloquinone (K1and menaquinone (K2)) are a group of fat-soluble vitamins essential for normal blood-clotting function. Menaquinone is synthesised by normal flora in the intestine although the amount produced in vivo in the human gut is likely negligible. Vitamin K serves as a coenzyme for the clotting factors II, VII, IX and X. Warfarin inhibits vitamin K by preventing its enzymatic reactivation. 

Pathological manifestations are rare. Hypervitaminosis K can lead to jaundice and anaemia in the neonate. 

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Article information

rID: 49232
System: Paediatrics
Section: Pathology
Synonyms or Alternate Spellings:

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