Vulval neoplasms

Last revised by Daniel J Bell on 5 Mar 2019

Vulval neoplasms are rare and mostly seen in elderly female patients. Squamous cell carcinoma (SCC) is the most common malignancy of the vulva and only 30% of them are associated with oncogenic human papillomaviruses (HPVs).


Squamous neoplastic lesions 
  • classic vulvar intraepithelial neoplasm (classic VIN): precursors of the basaloid SCCs
  • differentiated vulvar intraepithelial neoplasm (differentiated VIN): precursors of the keratinizing SCCs
Malignant squamous cell carcinoma
  • invasive basaloid and warty squamous cell carcinomas: 30% of cases, associated with human papillomavirus (HPV)
  • keratinizing squamous cell carcinoma: 70%, not associated with HPV
Glandular neoplastic lesions 
Malignant melanoma 

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