Vulval neoplasms

Last revised by Dr Daniel J Bell on 05 Mar 2019

Vulval neoplasms are rare and mostly seen in elderly female patients. Squamous cell carcinoma (SCC) is the most common malignancy of the vulva and only 30% of them are associated with oncogenic human papillomaviruses (HPVs).

Pathology

Squamous neoplastic lesions 
Premalignant 
  • classic vulvar intraepithelial neoplasm (classic VIN): precursors of the basaloid SCCs
  • differentiated vulvar intraepithelial neoplasm (differentiated VIN): precursors of the keratinizing SCCs
Malignant squamous cell carcinoma
  • invasive basaloid and warty squamous cell carcinomas: 30% of cases, associated with human papillomavirus (HPV)
  • keratinizing squamous cell carcinoma: 70%, not associated with HPV
Glandular neoplastic lesions 
Malignant melanoma 

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