Vulval neoplasms are rare and mostly seen in elderly female patients. Squamous cell carcinoma (SCC) is the most common malignancy of the vulva and only 30% of them are associated with oncogenic human papillomaviruses (HPVs).
Pathology
Squamous neoplastic lesions
Premalignant
- classic vulvar intraepithelial neoplasm (classic VIN): precursors of the basaloid SCCs
- differentiated vulvar intraepithelial neoplasm (differentiated VIN): precursors of the keratinising SCCs
Malignant squamous cell carcinoma
- invasive basaloid and warty squamous cell carcinomas: 30% of cases, associated with human papillomavirus (HPV)
- keratinising squamous cell carcinoma: 70%, not associated with HPV
Glandular neoplastic lesions
- similar to their breast lesion counterparts
- papillary hidradenoma
- extramammary Paget disease
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