Weber-Christian disease

Last revised by Dr Yuranga Weerakkody on 01 Apr 2021

Weber-Christian disease or Pfeifer-Weber-Christian disease or idiopathic relapsing febrile nodular non-suppurative panniculitis was initially defined as a rare inflammatory disorder of unknown etiology affecting subcutaneous adipose tissue inter alia 1.

However, the understanding of lobular panniculitis has expanded and cases that were once diagnosed in the "water basket" of “Weber-Christian” disease are with modern histology and immunopathology recognized to be clearly definable and separate entities comprising:

Most authors suggest the term be abandoned or even buried 2-4

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