WHO classification of eye tumors

Last revised by Craig Hacking on 20 Oct 2022

Citation, DOI, disclosures and article data

Citation:

Deng F, Hacking C, Buemi F, et al. WHO classification of eye tumors. Reference article, Radiopaedia.org (Accessed on 24 Apr 2024) https://doi.org/10.53347/rID-73167

DOI:

https://doi.org/10.53347/rID-73167

Permalink:

https://radiopaedia.org/articles/73167

rID:

73167

Article created:

28 Dec 2019, Francis Deng ◉

Disclosures:

At the time the article was created Francis Deng had no recorded disclosures.

View Francis Deng's current disclosures

Last revised:

20 Oct 2022, Craig Hacking ◉ ◈

Disclosures:

At the time the article was last revised Craig Hacking had the following disclosures:

Philips Australia, Paid speaker at Philips Spectral CT events (ongoing)

These were assessed during peer review and were determined to not be relevant to the changes that were made.

View Craig Hacking's current disclosures

Revisions:

12 times, by 8 contributors - see full revision history and disclosures

Systems:

Head & Neck

Sections:

Classifications, Pathology

Synonyms:

WHO classification of tumours of the eye
WHO classification of tumors of the eye
World Health Organization classification of eye tumors
World Health Organisation classification of eye tumours
WHO classification of eye tumours

The World Health Organizatiοn (WHO) classification of eye tumors is a widely used pathologic classification system of neoplasms of the orbit. The current revision, part of the 4^th edition of the WHO series, was published in 2018 and is reflected in the article below ¹.

Classification

Tumors of the conjunctiva and caruncle

epithelial tumors
- conjunctival squamous cell carcinoma
- conjunctival spindle cell carcinoma
- adenosquamous carcinoma
- keratoacanthoma
- hereditary benign intraepithelial dyskeratosis of the conjunctiva
- sebaceous carcinoma
- oncocytoma
- conjunctival squamous papilloma
  - tumor-like lesion
  - cysts
  - reactive epithelial hyperplasia
  - pseudoglandular and pseudoepitheliomatous hyperplasia
melanocytic tumors
- conjunctival melanoma
- conjunctival melanocytic intraepithelial neoplasia
- conjunctival junctional, compound, and subepithelial nevi
- inflamed juvenile conjunctival nevus
- blue nevus of the conjunctiva
- Spitz nevus of the conjunctiva
- benign epithelial melanosis of the conjunctiva
hematolymphoid tumors
- lymphomas
- papillary/follicular conjunctivitis
- reactive lymphoid hyperplasia
soft tissue tumors
- leiomyosarcoma
- rhabdomyosarcoma
- Kaposi sarcoma
- angiosarcoma
- fibrous histiocytoma
- conjunctival stromal tumor
- myxoma
- hemangioma
- lymphangioma
- neurofibroma
- schwannoma
- juvenile xanthogranuloma
hamartomas and choristomas
- epibulbar choristoma
- epibulbar osseous choristoma
- phakomatous choristoma
secondary tumors

Tumors of the iris, ciliary body, and choroid

tumors of the iris
- iris melanoma
- melanocytic nevus
- ocular melanocytosis
- Lisch nodule
- pigmented epithelial cyst
- implantation cyst
- ectopic lacrimal gland
- histiocytic tumors
tumors of the ciliary body
- uveal melanocytoma
- adenocarcinoma
- ciliary body adenoma
- adenomatous hyperplasia
- reactive epithelial hyperplasia
- medulloepithelioma of the ciliary body
- leiomyoma
- schwannoma
- glioneuroma
tumors of the choroid
- choroidal and ciliary body melanomas
- choroidal and ciliary body nevi
- bilateral diffuse uveal melanocytic hyperplasia
- neurofibroma and ganglioneuroma
- schwannoma
- hemangioma
- osteoma
- primary choroidal lymphoma
- secondary lymphomatous infiltration
- leukemic infiltration
secondary tumors

Tumors of the retina and retinal pigment epithelium

tumors of the neurosensory retina
- retinoblastoma
- retinocytoma
- astrocytic hamartoma and astrocytoma
- nodular and massive retinal gliosis
- hemangioblastoma
- cavernous hemangioma
- vitreoretinal lymphoma
- leukemic infiltration
- secondary tumors
tumors of the retinal pigment epithelium
- adenocarcinoma
- adenoma
- reactive hyperplasia
- simple and combined hamartomas
- congenital hypertrophy

Tumors of the optic disc and optic nerve

primary tumors
secondary tumors

Tumors of the lacrimal gland

epithelial tumors
- adenoid cystic carcinoma
- mucoepidermoid carcinoma
- carcinosarcoma
- carcinoma ex pleomorphic adenoma
- pleomorphic adenoma
- myoepithelial tumors
- oncocytic tumors
- rare neoplasms
  - epithelial-myoepithelial carcinoma
  - low-grade intraductal carcinoma
  - secretory carcinoma
  - hybrid neoplasms
  - acinic cell carcinoma
  - Warthin tumor
hematolymphoid tumors
- lymphomas
- reactive lymphoid hyperplasia
secondary tumors

Tumors of the lacrimal drainage system

epithelial tumors
- squamous cell carcinoma
  - non-keratinizing squamous cell carcinoma
- adenocarcinoma
- mucoepidermoid carcinoma
- adenoid cystic carcinoma
- lymphoepithelial carcinoma
- exophytic papilloma
- inverted papilloma
other tumors
- melanoma
- lymphomas
- secondary tumors