The World Health Organization (WHO) classification of prostate tumors is a commonly used classification system for prostate tumors. The current version was published in 2016 as part of the WHO Classification of Tumors of the Urinary System and Male Genital Organs 1,2 and replaces the previous classification from 2004:
Classification
Epithelial tumors
Glandular neoplasms
-
cribriform
papillary
solid
Squamous neoplasms
Neuroendocrine tumors
Mesenchymal tumors
angiosarcoma
synovial sarcoma
inflammatory myofibroblastic tumor
osteosarcoma
undifferentiated pleomorphic sarcoma
solitary fibrous tumor
malignant solitary fibrous tumor
hemangioma
granular cell tumor
Haematolymphoid tumors
diffuse large B-cell lymphoma
chronic lymphocytic leukemia/small lymphocytic lymphoma
follicular lymphoma
mantle cell lymphoma
acute myeloid leukemia
B lymphoblastic leukemia/lymphoma
Miscellaneous tumors
nephroblastoma
rhabdoid tumor
germ cell tumor
clear cell adenocarcinoma
paraganglioma
neuroblastoma
Metastatic tumors
Tumor of the seminal vesicles
Epithelial tumors
squamous cell carcinoma
Mixed epithelial and stromal tumors
Mesenchymal tumors
leiomyoma
schwannoma
mammary-type myofibroblastoma
gastrointestinal stromal tumor, NOS
leiomyosarcoma
angiosarcoma
liposarcoma
solitary fibrous tumor
hemangiopericytoma
Miscellaneous tumors
choriocarcinoma
seminoma
well-differentiated neuroendocrine tumor/carcinoid tumor
lymphomas
Ewing sarcoma
Metastatic tumors
Changes from prior versions
Modifications to the Gleason grading system were incorporated into the new version among those:
cribriform glands and glomeruloid glands should be graded as Gleason 4
grading of mucinous carcinoma of the prostate should be according to the growth pattern
New entities and variants
Newly introduced entities include:
Newly introduced variants include:
microcystic adenocarcinoma
pleomorphic giant cell adenocarcinoma
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