WHO classification of tumors of hematopoietic and lymphoid tissues

The World Health Organization (WHO) classification of tumors of hematopoietic and lymphoid tissues is the most widely used pathologic classification system for hematolymphoid neoplasms. The current revision, known as the 4th revised edition, was published in 2016 and supersedes the 4th edition published in 2008.

The current 2016 version forms the basis of the article below 1-3.

Classification

Myeloid neoplasms
  • myeloproliferative neoplasms
  • mastocytosis
    • cutaneous mastocytosis
    • systemic mastocytosis
      • indolent systemic mastocytosis
      • smoldering systemic mastocytosis
      • systemic mastocytosis with an associated hematological neoplasm
      • aggressive systemic mastocytosis
      • mast cell leukemia
    • mast cell sarcoma
  • myeloid/lymphoid neoplasms with eosinophilia and gene rearrangement
    • myeloid/lymphoid neoplasms with PDGFRA rearrangement
    • myeloid/lymphoid neoplasms with PDGFRB rearrangement
    • myeloid/lymphoid neoplasms with FGFR1 rearrangement
    • myeloid/lymphoid neoplasms with PCM1-JAK2 (provisional entity)
  • myelodysplastic/myeloproliferative neoplasms
    • chronic myelomonocytic leukemia
    • atypical chronic myeloid leukemia, BCR-ABL1-negative
    • juvenile myelomonocytic leukemia
    • myelodysplastic/myeloproliferative neoplasm with ring sideroblasts and thrombocytosis
    • myelodysplastic/myeloproliferative neoplasm, unclassifiable
  • myelodysplastic syndromes
    • myelodysplastic syndrome with single lineage dysplasia
    • myelodysplastic syndrome with multilineage dysplasia
    • myelodysplastic syndrome with ring sideroblasts
      • myelodysplastic syndrome with ring sideroblasts and single lineage dysplasia
      • myelodysplastic syndrome with ring sideroblasts and multilineage dysplasia
    • myelodysplastic syndrome with excess blasts
    • myelodysplastic syndrome with isolated del(5q)
    • myelodysplastic syndrome, unclassifiable
    • refractory cytopenia of childhood (provisional entity)
  • myeloid neoplasms with germline predisposition
    • myeloid neoplasms with germline predisposition without a preexisting disorder or organ dysfunction
      • acute myeloid leukemia with germline CEBPA mutation
      • myeloid neoplasms with germline DDX41 mutation
    • myeloid neoplasms with germline predisposition and preexisting platelet disorders
      • myeloid neoplasms with germline RUNX1 mutation
      • myeloid neoplasms with germline ANKRD26 mutation
      • myeloid neoplasms with germline ETV6 mutation
    • myeloid neoplasms with germline predisposition and other organ dysfunction
      • myeloid neoplasms with germline GATA2 mutation
      • myeloid neoplasms associated with bone marrow failure syndromes
      • myeloid neoplasms associated with telomere biology disorders
      • juvenile myelomonocytic leukemia associated with neurofibromatosisNoonan syndrome or Noonan syndrome-like disorders
      • myeloid neoplasms associated with Down syndrome
  • acute myeloid leukemia and related neoplasms
    • acute myeloid leukemia with recurrent genetic abnormalities
      • acute myeloid leukemia with t(8;21)(q22;q22.1); RUNX1-RUNX1T1
      • acute myeloid leukemia with inv(16)(p13.1q22) or t(16;16)(p13.1;q22); CBFB-MYH11
      • acute promyelocytic leukemia with PML-RARA
      • acute myeloid leukemia with t(9;11)(p21.3;q23.3); MLLT3-KMT2A
      • acute myeloid leukemia with t(6;9)(p23;q34.1); DEK-NUP214
      • acute myeloid leukemia with inv(3)(q21.3q26.2) or t(3;3)(q21.3;q26.2); GATA2MECOM
      • acute myeloid leukemia (megakaryoblastic) with t(1;22)(p13.3;q13.3); RBM15-MKL1
      • acute myeloid leukemia with BCR-ABL1 (provisional entity)
      • acute myeloid leukemia with mutated NPM1
      • acute myeloid leukemia with biallelic mutations of CEBPA
      • acute myeloid leukemia with mutated RUNX1 (provisional entity)
    • acute myeloid leukemia with myelodysplasia-related changes
    • therapy-related myeloid neoplasms
    • acute myeloid leukemia, not otherwise specified
      • acute myeloid leukemia with minimal differentiation
      • acute myeloid leukemia without maturation
      • acute myeloid leukemia with maturation
      • acute myelomonocytic leukemia
      • acute monoblastic/monocytic leukemia
      • pure erythroid leukemia
      • acute megakaryoblastic leukemia
      • acute basophilic leukemia
      • acute panmyelosis with myelofibrosis
    • myeloid sarcoma
    • myeloid proliferations related to Down syndrome
      • transient abnormal myelopoiesis
      • myeloid leukemia associated with Down syndrome
  • blastic plasmacytoid dendritic cell neoplasm
  • acute leukemias of ambiguous lineage
    • acute undifferentiated leukemia
    • mixed phenotype acute leukemia with t(9;22)(q34.1;q11.2); BCR-ABL1
    • mixed phenotype acute leukemia with t(v;11q23.3); KMT2A rearranged
    • mixed phenotype acute leukemia, B/myeloid, not otherwise specified
    • mixed phenotype acute leukemia, T/myeloid, not otherwise specified
Lymphoid neoplasms
Histiocytic and dendritic cell neoplasms

See also

Lymphoma
Share article

Article information

rID: 9250
Synonyms or Alternate Spellings:
  • WHO classification of tumours of haematopoietic and lymphoid tissues
  • World Health Organization classification of tumors of hematopoietic and lymphoid tissues
  • World Health Organisation classification of tumours of haematopoietic and lymphoid tissues
  • WHO classification of lymphoma
  • WHO classification of leukaemia
  • WHO classification of neoplastic diseases of lymphoid tissues
  • WHO classification of tumors of hematopoietic and lymphoid tissues

Support Radiopaedia and see fewer ads

Cases and figures

  • T Cell Lymphoma CT
    Case 1: T-cell lymphoma
    Drag here to reorder.
  • Case 2: vertebral body B cell lymphoma
    Drag here to reorder.
  • Case 3: mediastinal large B-cell lymphoma
    Drag here to reorder.
  • Case 4: small lymphocytic lymphoma
    Drag here to reorder.
  • Updating… Please wait.

     Unable to process the form. Check for errors and try again.

     Thank you for updating your details.