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WHO classification of tumors of the uterine cervix (5th edition)

Last revised by Henry Knipe ◉ on 9 Mar 2025

Citation, DOI, disclosures and article data

Citation:

Weerakkody Y, Knipe H, Hacking C, WHO classification of tumors of the uterine cervix (5th edition). Reference article, Radiopaedia.org (Accessed on 20 Mar 2025) https://doi.org/10.53347/rID-17954

DOI:

https://doi.org/10.53347/rID-17954

Permalink:

https://radiopaedia.org/articles/17954?embed_domain=hackmd.io%2F%40yipuafecsl2jsu8smr5njq%2Fbnjhjgjghjghjghfavicon.icofavicon.ico

rID:

17954

Article created:

27 May 2012, Yuranga Weerakkody ◉

Disclosures:

At the time the article was created Yuranga Weerakkody had no recorded disclosures.

View Yuranga Weerakkody's current disclosures

Last revised:

9 Mar 2025, Henry Knipe ◉

Disclosures:

At the time the article was last revised Henry Knipe had the following disclosures:

Micro-X Ltd, Shareholder (past)

These were assessed during peer review and were determined to not be relevant to the changes that were made.

View Henry Knipe's current disclosures

Revisions:

4 times, by 3 contributors - see full revision history and disclosures

Systems:

Gynaecology, Oncology

Sections:

Classifications

Tags:

refs, cases, case3

Synonyms:

WHO histological classification of tumours of the cervix
WHO histological classification of cervical tumours

The 2020 WHO classification of female genital tumors (5th edition) includes a detailed classification of tumors of the uterine cervix ^1,2.

Classification

Squamous epithelial tumors

mimics of squamous precursor lesions
- squamous metaplasia
- atrophy of the uterine cervix
squamous cell tumors and precursors
- condyloma acuminatum
- squamous intraepithelial lesions
- squamous cell carcinoma, HPV-associated
- squamous cell carcinoma, HPV-independent
- squamous cell carcinoma NOS

Glandular tumors and precursors

benign glandular lesions
- endocervical polyp
- Mullerian papilloma
- Nabothian cyst
- tunnel clusters
- microglandular hyperplasia
- lobular endocervical glandular hyperplasia
- diffuse laminar endocervical hyperplasia
- mesonephric remnants and hyperplasia
- Arias-Stella reaction
- endocervicosis
- tuboendometrioid metaplasia
- ectopic prostate tissue
adenocarcinomas
- adenocarcinoma in situ, HPV-associated
- adenocarcinoma, HPV-associated
- adenocarcinoma in situ, HPV-independent
- adenocarcinoma, HPV-independent, gastric type
- adenocarcinoma, HPV-independent, clear cell type
- adenocarcinoma, HPV-independent, mesonephric type
- other adenocarcinomas
other epithelial tumors
- carcinosarcoma
- adenosquamous and mucoepidermoid carcinomas
- adenoid basal carcinoma
- carcinoma of the uterine cervix, unclassifiable
mixed epithelial and mesenchymal tumors
- adenomyoma
- adenosarcoma
germ cell tumors

References

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