Widening of diploic space
Widening of diploic space refers to diffuse, most commonly bilateral, calvarium widening secondary to extramedullary hematopoiesis within the skull.
Most commonly caused by systemic underlying pathologies such as:
- chronic haemolytic disorders: may be associated with vertical striations running in diploic space giving rise to the characteristic hair on end sign
- metabolic disorders
- 1. Lloret I et al, Calvarial Lesions: A Radiological Approach to Diagnosis, Acta Radiologica 2009, 50:5, 531-542
- 2. Hollar M, The Hair-on-End Sign, Radiology Signs in Imaging, November 2001 Volume 221, Issue 2