Widening of the diploic space

Last revised by Mohamed Saber on 26 Oct 2020

Widening of the diploic space refers to expansion of the cancellous (spongy) bone between the inner and outer tables of the calvaria. The diploic space is the medullary cavity of the skull, and a location of normal physiologic hematopoiesis in adults. Thus, expansion of this structure most commonly occurs in the setting of chronically increased intramedullary hematopoiesis. The widened appearance is most commonly bilateral.


Most commonly caused by systemic pathologies such as:

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Cases and figures

  • Case 1: thalassemia major
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