Revision 17 for 'Xanthogranulomatous cholecystitis'

All Revisions - View changeset

Xanthogranulomatous cholecystitis

Xanthogranulomatous cholecystitis is an uncommon inflammatory disease of the gallbladder which may be difficult to differentiate from malignancy, both on imaging and pathologically. It is characterized by presence of multiple intramural nodules.


It is seen predominantly in female patients in their 60s or 70s.

Clinical presentation

Patients typically present with symptoms and signs similar to cholecystitis: right upper quadrant pain with a positive Murphy's sign. Leukocytosis is generally present.


The macroscopic appearance is of a poorly defined, nodular yellow mass that infiltrates the wall of the gallbladder.  There is gallbladder wall thickening, and the process may infiltrate directly into the adjacent soft tissues, liver, duodenum or colon1.

Histologically, it consists of a mixture of ceroid (waxlike) xanthogranuloma with foamy histiocytes, multinucleated foreign body giant cells, lymphocytes and fibroblasts containing areas of necrosis.

It is postulated that xanthogranulomatous cholecystitis results from rupture of occluded Rokitansky-Aschoff sinuses, with subsequent intramural extravasation of inspissated bile and mucin3.  This further attracts histiocytes to phagocytize the insoluble cholesterol.

Spectrum of pathological findings includesref needed:

  • thickened gallbladder wall : 91% diffuse, 9% focal
  • infiltration of pericholecystic fat: in 45% focal, in 54% diffuse
  • hepatic extension : ~ 45 %
  • biliary obstruction : ~ 36 %
  • lymphadenopathy : ~ 36 %

Radiographic features

  • gallbladder wall thickening may be diffuse or focal
  • intramural hypo-echoic nodules or bands
  • if the inflammatory process has infiltrated the adjacent liver, there may be loss of the intervening fat plane, with focal hypo-attenuation of hepatic parenchyma.
  • gallstones often present
  • 5 - 20 mm small intra-mural hypo-attenuating nodules
  • poor / heterogeneous contrast enhancement
  • features of local infiltration, or other complications, such as perforation, abscess formation or formation of fistulous tracts 1.

Differential diagnosis

Updating… Please wait.

 Unable to process the form. Check for errors and try again.

 Thank you for updating your details.