Yellow nail syndrome

The yellow nail syndrome (YNS) is rare disorder principally affecting lymphatic system

It is characterised by 

  • nail discolouration: yellow slow growing dystrophic nails
  • peripheral / primary lymphoedema
  • pulmonary manifestations

Other associated features include

There may be a slightly increased female predilection 5. While clinical onset varies from birth to late adult life, it is thought to typically those in early middle age 5.

The syndrome can sometimes be associated with 

The exact pathogenesis is not well known although anatomical or functional lymphatic drainage abnormalities have been proposed as an underlying mechanism.

Clinical features can be variable among individuals with this disorder, and these features can vary over time. 

Imaging is often performed in the evaluation of pulmonary manifestations.

While individual features are non specific, there may be evidence of

While there is no specific treatment for the syndrome, most patients are often managed with supportive measures targeted at ameliorating the various clinical manifestations (e.g. treating respiratory infections).

The general clinical course is benign but can depend on underlying associations.

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Article information

rID: 27538
System: Chest, Vascular
Synonyms or Alternate Spellings:
  • Yellow nail syndrome (YNS)
  • YNS

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