Citation, DOI & article data
Yttrium-90 (90Y) is a radioisotope; derived from the decay of 90Sr.
Yttrium-90 decays due to the emission of β- particles, with a half-life of 2.67 days 5. It can be used for metabolic radiopharmaceutical therapy, for example: non-Hodgkin B-cell lymphoma radioimmunotherapy (radiopharmaceutical therapy and immunotherapy). The radiopharmaceutical used is 90Y-ibritumomab tiuxetan; it is a murine monoclonal antibody (mAb) directed at human CD20. Radioactive yttrium is bound to the mAb through the tiuxetan, a bifunctional chelator.
Colloidal yttrium-90 citrate is the radiopharmaceutical used in radiosynoviorthesis (RSO), the radionuclide therapy for the treatment of joint inflammation 4.
Yttrium belongs to the group of transition metals; it has atomic number (Z) 39 and atomic weight 88.90585
Its electronic configuration is: [Kr] 4d1 5s2
The maximum energy of the emitted particles is 2.28 MeV with an average path in the human tissuses of approximately 5.8 mm. It decays in the non-radioactive isotope 90Zr.
History and etymology
Yttrium was discovered in 1794 by Johan Gadolin, a Finnish chemist, in a sample of mineral originating from Ytterby (Sweden).
- 1. Hagenbeek A. Radioimmunotherapy for NHL: Experience of 90Y-Ibritumomab Tiuxetan in Clinical Practice. Leuk Lymphoma. 2003;44 Suppl 4(sup4):S37-47. doi:10.1080/10428190310001616944 - Pubmed
- 2. Chinol M & Hnatowich D. Generator-Produced Yttrium-90 for Radioimmunotherapy. J Nucl Med. 1987;28(9):1465-70. - Pubmed
- 3. Robert E. Krebs. The History and Use of Our Earth's Chemical Elements. (2006) ISBN: 9780313334382 - Google Books
- 4. Szentesi M, Nagy Z, Géher P, Papp I, Kampen W. A Prospective Observational Study on the Long-Term Results of Yttrium Citrate Radiosynoviorthesis of Synovitis in Osteoarthritis of the Knee Joint. Eur J Nucl Med Mol Imaging. 2019;46(8):1633-41. doi:10.1007/s00259-019-04350-3 - Pubmed
- 5. Kim S, Cohalan C, Kopek N, Enger S. A Guide to 90Y Radioembolization and Its Dosimetry. Phys Med. 2019;68:132-45. doi:10.1016/j.ejmp.2019.09.236 - Pubmed