Z line

Andrew Murphy and Dr Matt A. Morgan et al.

The Z line in the esophagus is the term for a faint zig-zag impression at the gastro-esophageal junction that demarcates the transition between the stratified squamous epithelium in the esophagus and the intestinal epithelium of the gastric cardia (the squamocolumnar junction).

The Z line is a normal finding but is not seen in every study. An irregular or elevated Z line indicates potential distal esophageal metaplasia / Barrett esophagus, although the actual risk of this finding is debated.

Article information

rID: 78026
Synonyms or Alternate Spellings:
  • Squamocolumnar junctions
  • Squamocolumnar junction
  • Z lines
  • High Z line
  • Irregular Z line

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Cases and figures

  • Case 1a
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  • Case 1b: normal Z line outlined in red
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