The zebra stripe sign occurs where children with osteogenesis imperfecta have been treated with cyclical bisphosphonate therapy, e.g. pamidronate. When the drug is delivered in cycles, dense bone is formed while treatment is being given. This results in dense stripes across the metaphyses of bones which can be visualized radiographically.
The "zebra stripe sign" 1 is not to be confused with the "zebra sign" 2, which refers to remote cerebellar hemorrhage.
- 1. Al Muderis M, Azzopardi T, Cundy P. Zebra lines of pamidronate therapy in children. J Bone Joint Surg Am 2007;89 (7): 1511-6. doi:10.2106/JBJS.F.00726 - Pubmed citation
- 2. Brockmann MA, Nowak G, Reusche E et-al. Zebra sign: cerebellar bleeding pattern characteristic of cerebrospinal fluid loss. Case report. J. Neurosurg. 2005;102 (6): 1159-62. doi:10.3171/jns.2005.102.6.1159 - Pubmed citation