Zinner syndrome

Zinner syndrome is a triad of Wolffian duct anomalies that includes unilateral renal agenesis, ipsilateral seminal vesicle cyst, and ejaculatory duct obstruction 1.

Patients are typically diagnosed at 3rd or 4th decade of life and often present with perineal pain, recurrent prostatitis, haematospermia, painful ejaculation, and infertility 1.

There is an association between congenital malformations of the seminal vesicle and ipsilateral upper urinary tract because both ureteral buds and seminal vesicles originate from the mesonephric (Wolffian) duct 2,3.

Maldevelopment of the distal part of the mesonephric duct results in atresia of the ejaculatory duct (leading to obstruction and dilatation of the seminal vesicle), while an abnormality in the ureteral bud leads to renal agenesis/dysplasia 1.

Irrespective of imaging modality, the key findings are 1:

  • unilateral renal agenesis
  • ipsilateral ejaculatory duct obstruction
  • ipsilateral seminal vesicle cyst

In asymptomatic patients, treatment is usually conservative, however, symptomatic patients are often treated surgically 5.

Seminal vesicles should be differentiated from other cysts such as 4

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Article information

rID: 30469
System: Urogenital
Section: Syndromes
Synonyms or Alternate Spellings:
  • Zinner's syndrome
  • Seminal vesicle cyst and ipsilateral renal agenesis
  • Seminal vesicle cyst and renal agenesis

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