Citation, DOI & article data
Zuckerkandl tubercles are the projections of normal thyroid tissue from the posterior or posteromedial margin of the thyroid gland that extend posterior to the tracheoesophageal groove. They are present in most patients and occur more commonly on the right and in the longitudinal center 50% of the lobe 1,2.
The tubercle is an important surgical landmark as the recurrent laryngeal nerve passes immediately medial to it 3.
When it has a pedunculated or nodular appearance, sometimes due to the lateral impression of the common carotid artery, the tubercle can be mistaken for a thyroid nodule, enlarged parathyroid, or lymph node 1. Recognizing this finding as a normal variant is important for avoiding unnecessary concern. However, it should be noted that disease (e.g. thyroid cancer) can still occur within this structure.
History and etymology
Named after Emil Zuckerkandl (1849-1910) 4, Professor of Anatomy at the University of Vienna, who described it in 1902.
- 1. Lee TC, Selvarajan SK, Curtin H et-al. Zuckerkandl tubercle of the thyroid: a common imaging finding that may mimic pathology. AJNR Am J Neuroradiol. 2012;33 (6): 1134-8. doi:10.3174/ajnr.A2914 - Pubmed citation
- 2. Won HJ, Won HS, Kwak DS et-al. Zuckerkandl Tubercle of the Thyroid Gland: Correlations between Findings of Anatomic Dissections and CT Imaging. AJNR Am J Neuroradiol. 2017;38 (7): 1416-1420. doi:10.3174/ajnr.A5172 - Pubmed
- 3. Yalçin B, Poyrazoglu Y, Ozan H. Relationship between Zuckerkandl's tubercle and the inferior laryngeal nerve including the laryngeal branches. Surg Today. 2007;37 (2): 109-13. doi:10.1007/s00595-006-3346-y - Pubmed citation
- 4. Winer L, Jha P, Cowan SW, Yeo CJ, Goldstein SD. Emil Zuckerkandl, M.D. (1849-1910): Bridging Anatomic Study and the Operating Room Table. (2016) The American surgeon. 82 (3): 189-91. Pubmed