Pituitary macroadenomas are the most common suprasellar mass in adults, and responsible for the majority of trans-sphenoidal hypophysectomy.

On imaging, they usually present as a solid tumor and demonstrates moderate contrast enhancement. They are isointense to the grey matter both on T1 and T2-weighted images. However, signal characteristics can significantly vary depending on tumor components such as hemorrhage, cystic transformation or necrosis.