Benign enlargement of subarachnoid space in infancy

Case contributed by Shimalis Tadasa Fayisa , 11 Jul 2022
Diagnosis certain
Changed by Henry Knipe, 26 Jul 2022
Disclosures - updated 6 Apr 2022:
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  • Micro-X Ltd, Shareholder (ongoing)

Updates to Case Attributes

Status changed from pending review to published (public).
Published At was set to .
Age changed from 09 month to 9 months.
Presentation was changed:
largeLarge head.
Body was changed:

benignBenign enlargement of the subarachnoid space (BESS) in infancy, also called benign external hydrocephalus or extraventricular hydrocephalus.is, is the most common cause of macrocephaly.

Large head circumference, normal or minor motor and linguistic delay, increased cerebrospinal fluid (CSF) in the subarachnoid space, and normal ventricles or mild ventriculomegaly are some of its clinical characteristics.

Although the aetiology of increased subarachnoid spaces is unknown, arachnoid villi that have not fully developed have been believed to be the reason and by the age of two years, the majority of the causescases resolve on their own.

The diagnosis of BESS may be complicated by other mimicking diagnosis like;-diagnoses such as:

1, brain

  • Brain atrophy there is symetrical: Symmetrical enlargement offrontal, parietal, temporal, and occipital lobes subarachnoid space, and the cerebral sulcus widens without increasing the size of the head.

    2,subdural

  • Subdural collection have displaced: Displace bridging veins from the inner table.

    3,hydrocephalus There is a considerable

  • Hydrocephalus: Considerable enlargement of the ventricles, but there is no sign of blockageobstruction, periventricular lucency, or transependymal oedema.
  • -<p>benign enlargement of subarachnoid space also called benign external hydrocephalus extraventricular hydrocephalus.is the most common cause of macrocephaly.</p><p>Large head circumference, normal or minor motor and linguistic delay, increased cerebrospinal fluid (CSF) in the subarachnoid space, and normal ventricles or mild ventriculomegaly are some of its clinical characteristics.</p><p>Although the aetiology of increased subarachnoid spaces is unknown, arachnoid villi that have not fully developed have been believed to be the reason and by the age of two years, the majority of the causes resolve on their own.</p><p>The diagnosis of BESS may be complicated by other mimicking diagnosis like;-</p><p>1, brain atrophy there is symetrical enlargement of frontal, parietal, temporal, and occipital lobes subarachnoid space , and the cerebral sulcus widens without increasing the size of the head.</p><p>2,subdural collection have displaced bridging veins from inner table.</p><p>3,hydrocephalus There is a considerable enlargement of the ventricles , but there is no sign of blockage, periventricular lucency, or transependymal oedema.</p>
  • +<p><a title="Benign enlargement of the subarachnoid space in infancy" href="/articles/benign-enlargement-of-the-subarachnoid-space-in-infancy">Benign enlargement of the subarachnoid space (BESS) in infancy</a>, also called benign external hydrocephalus or extraventricular hydrocephalus, is the most common cause of macrocephaly.</p><p>Large head circumference, normal or minor motor and linguistic delay, increased cerebrospinal fluid (CSF) in the subarachnoid space, and normal ventricles or mild ventriculomegaly are some of its clinical characteristics.</p><p>Although the aetiology of increased subarachnoid spaces is unknown, arachnoid villi that have not fully developed have been believed to be the reason and by the age of two years, the majority of cases resolve on their own.</p><p>The diagnosis of BESS may be complicated by other mimicking diagnoses such as:</p><ul>
  • +<li>Brain atrophy: Symmetrical enlargement of frontal, parietal, temporal, and occipital lobes subarachnoid space, and the cerebral sulcus widens without increasing the size of the head.</li>
  • +<li>Subdural collection: Displace bridging veins from the inner table.</li>
  • +<li>Hydrocephalus: Considerable enlargement of the ventricles, but there is no sign of obstruction, periventricular lucency, or transependymal oedema.</li>
  • +</ul>

References changed:

  • 2. Khosroshahi N & Nikkhah A. Benign Enlargement of Subarachnoid Space in Infancy: "A Review with Emphasis on Diagnostic Work-Up". Iran J Child Neurol. 2018;12(4):7-15. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6160631">PMC6160631</a> - <a href="https://www.ncbi.nlm.nih.gov/pubmed/30279704">Pubmed</a>
  • 1. Biswas A, Furruqh F, Thirunavukarasu S, Neelakantan S. Benign Enlargement of Subarachnoid Spaces: A Cause of Subdural Haemorrhage in Toddlers. BMJ Case Rep. 2016;2016:bcr2016215753. <a href="https://doi.org/10.1136/bcr-2016-215753">doi:10.1136/bcr-2016-215753</a> - <a href="https://www.ncbi.nlm.nih.gov/pubmed/27143167">Pubmed</a>
  • 3, Eurorad.org. Eurorad - Brought to You by the ESR.
  • 2, Khosroshahi N, Nikkhah A. Benign Enlargement of Subarachnoid Space in Infancy: "A Review with Emphasis on Diagnostic Work-Up". Iran J Child Neurol. 2018 Fall;12(4):7-15. PMID: 30279704; PMCID: PMC6160631.
  • 1, Biswas A, Furruqh F, Thirunavukarasu S, et al Benign enlargement of subarachnoid spaces: a cause of subdural haemorrhage in toddlers Case Reports 2016;2016:bcr2016215753.

Systems changed:

  • Central Nervous System

Updates to Study Attributes

Caption was removed:
brain MRI with contrast
Findings was changed:

-WidenedWidened bilateral frontoparietal, anterior interhemispheric and bilateral anterior temporal lobe CSF spaces.

-cortical Cortical veins are not displaced and lie adjacent to the inner table of the calvaria.

-no No flattening of adjacent gyri

-normal. Normal sulci posteriorly

-normal. Normal ventricular size and no pressure on adjacent brain tissue

-no. No abnormal enhancing brain parenchyma seen.

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