This case demonstrates the typical imaging appearances of ATTR cardiac amyloidosis on nuclear medicine amyloidosis study. The combination of planar imaging and SPECT-CT improves the anatomical localization of the abnormal tracer uptake in these studies.

Fused SPECT-CT images are particularly useful in cases where there is less intense accumulation of tracer in the heart. In these cases, SPECT-CT allows distinction of physiological blood pool avidity and abnormal myocardial uptake.