What is primary and secondary callosal dysgenesis?
Primary agenesis is where the corpus callosum never forms. Secondary dysgenesis is where corpus callosum is formed but subsequently destroyed.
What are the common aneuploidy syndromes associated with corpus callosum dysgenesis?
Trisomy 18. Trisomy 13. Trisomy 8.
What is the commonest CNS association with corpus callosum dysgenesis?
Dandy Walker spectrum.
When does the corpus callosum develop embryologically?
Between the 12th and 16th weeks of gestation.
Wide spacing of the occipital horns of the lateral ventricles (partial racing car sign), suggestive of dysgenesis of the splenium of the corpus callosum.
Widening of the subarachnoid spaces anteriorly.