The incidence of central nervous system (CNS) metastases in patients with melanoma ranges from 10% to 40% in clinical studies and is even higher in autopsy series with as many as two-thirds of patients with metastatic melanoma having CNS involvement.
This case shows post-surgical changes in the right orbit with the presence of a lesion in relation to residual tumor activity of a known primary tumor; likewise, intraventricular and infundibular pituitary lesions are associated with metastatic tumor activity.