Transfusion associated circulatory overload
Updates to Case Attributes
Patients presenting with SOBshortness of breath and tachypnoea immediately after transfusion should increase suspicion of pulmonary complications. With signs of increased pulmonary venous hydrostatic pressure such as pulmonary oedema and pleural effusion, this case is most consistent with transfusion-associated circulatory overload (TACO). Patients who develop TACO have increased susceptibility to volume overload due to heart failure, renal dysfunction, hypoalbuminaemia, or positive fluid balance.
This case was submitted with supervision and input from:Soni C. Chawla, M.D.Health Sciences Clinical Professor,Department of Radiological Sciences,David Geffen School of Medicine at UCLA.Attending Radiologist,Olive View - UCLA Medical Centre.
-<p>Patients presenting with SOB and tachypnoea immediately after transfusion should increase suspicion of pulmonary complications. With signs of increased pulmonary venous hydrostatic pressure such as pulmonary oedema and pleural effusion, this case is most consistent with transfusion-associated circulatory overload (TACO). Patients who develop TACO have increased susceptibility to volume overload due to heart failure, renal dysfunction, hypoalbuminaemia, or positive fluid balance.</p><p> </p><p><em>This case was submitted with supervision and input from:<br>Soni C. Chawla, M.D.<br>Health Sciences Clinical Professor,<br>Department of Radiological Sciences,<br>David Geffen School of Medicine at UCLA.<br>Attending Radiologist,<br>Olive View - UCLA Medical Centre.</em></p>- +<p>Patients presenting with shortness of breath and tachypnoea immediately after transfusion should increase suspicion of pulmonary complications. With signs of increased pulmonary venous hydrostatic pressure such as pulmonary oedema and pleural effusion, this case is most consistent with transfusion-associated circulatory overload (TACO). Patients who develop TACO have increased susceptibility to volume overload due to heart failure, renal dysfunction, hypoalbuminaemia, or positive fluid balance.</p><p> </p><p><em>This case was submitted with supervision and input from:<br>Soni C. Chawla, M.D.<br>Health Sciences Clinical Professor,<br>Department of Radiological Sciences,<br>David Geffen School of Medicine at UCLA.<br>Attending Radiologist,<br>Olive View - UCLA Medical Centre.</em></p>
References changed:
- Semple J, Rebetz J, Kapur R. Transfusion-Associated Circulatory Overload and Transfusion-Related Acute Lung Injury. Blood. 2019;133(17):1840-53. <a href="https://doi.org/10.1182/blood-2018-10-860809">doi:10.1182/blood-2018-10-860809</a> - <a href="https://www.ncbi.nlm.nih.gov/pubmed/30808638">Pubmed</a>
- Vlaar A & Veelo D. The First Steps in Understanding of Transfusion-Associated Circulatory Overload-We Are on a "Roll". Crit Care Med. 2018;46(4):650-1. <a href="https://doi.org/10.1097/CCM.0000000000002971">doi:10.1097/CCM.0000000000002971</a> - <a href="https://www.ncbi.nlm.nih.gov/pubmed/29538118">Pubmed</a>
- Semple JW, Rebetz J, Kapur R. Transfusion-associated circulatory overload and transfusion-related acute lung injury. Blood. 2019 Apr 25;133(17):1840-1853. doi: 10.1182/blood-2018-10-860809. Epub 2019 Feb 26. PMID: 30808638.
- Vlaar APJ, Veelo DP. The First Steps in Understanding of Transfusion-Associated Circulatory Overload-We Are on a "Roll". Crit Care Med. 2018 Apr;46(4):650-651. doi: 10.1097/CCM.0000000000002971. PMID: 29538118.
Updates to Link Attributes
Updates to Link Attributes
Updates to Study Attributes
Moderate diffuse bilateral pulmonary vascular congestion and interstitial edema with diffuse bronchial wall thickening and Kerley B lines mainly in the mid and lower lung zones are compatible with pulmonary edema from transfusion associated circulatory overload givenhistory of transfusion.
No discrete large effusion or pneumothorax. No discrete focal pneumonia.
Heart appears at upper limits normal with mild diffuse prominence of the main PApulmonary artery.
No acute osseous findings. No free air in the upper abdomen.