Alobar holoprosencephaly

Discussion:

Above mentioned findings are likely in keeping with alobar holoprosencephaly. It is the most severe form of holoprosencephaly with less severe forms being semilobar and lobar types. It results from incomplete cleavage of the prosencephalon.

Facial abnormalities associated with holoprosencephaly include cyclopia, ethmocephaly, cebocephaly, midline cleft lip, lateral cleft lip, and hypotelorism.

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