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MRI demonstrates generalized cerebral volume loss, more accentuated in the frontoparietal regions, with relative sparing of the temporal and occipital lobes. The hippocampi and mesial temporal lobes are not particularly volume depleted and have normal signal on FLAIR.
No convincing atrophy of the striatum or midbrain is present. The hypothalamic region may be a little more volume deplete than the rest of the brain. No convincing iron deposition in the globus pallidi and no 'eye of the tiger sign'.