Pathology
Formalin-fixed paraffin-embedded tissue after a left parietal craniotomy and tumour resection.
Description: The tumour shows meningothelial architecture in areas and fascicular in others infiltrating to the fibrous stroma (transitional type). There are multiple foci of psammomatous calcification. The cells show moderate variation in nuclear size with frequent nuclear pseudoinclusions. There is no sheetlike architecture or necrosis. Mitotic activity is infrequent.
In one fragment, peripherally there is glial tissue which is focally infiltrated by meningioma. Multifocal infiltration is confirmed on synaptophysin immunohistochemistry.