With which maternal condition is caudal regression syndrome most commonly associated?
Diabetes mellitus. Up to 22% of cases of caudal regresssion syndrome are associated with either type I or type II diabetes mellitus in the mother.
What abnormalities are commonly associated with caudal regression syndrome?
Genitourinary and anorectal anomalies, other spinal anomalies, tethered cord, orthopaedic abnormalities, congenital cardiac defects and pulmonary hypoplasia.
Myelogram and MRI demonstrate abnormally high termination of the spinal cord (at the superior aspect of L1) with a blunted wedge-shaped appearance of the conus. Prominence of the central canal is present within the mid-lower thoracic spine. There is dysgenesis of the sacrum, which appears truncated.