Since the previous investigation, there has been significant progressive FLAIR signal change extending into the left posterior parietal and occipital lobes. There is avid, nodular enhancement along the peripheral margin of the FLAIR signal abnormality both in the parietal and occipital lobes. The enhancement pattern is distinctly limited to the typical "advancing front" (open ring enhancement) of active demyelinating plaque. The enhancing nodularity demonstrates restricted diffusion. Previous right occipital biopsy site noted. The volume of FLAIR signal abnormality related to the posterior right parietal and occipital lobes has substantially reduced. The small region of nodular enhancement visible in the more anterior component of the FLAIR signal abnormality has completely resolved. T2 signal abnormality in the tail of the corpus callosum remains visible. The remainder of the brain is within normal limits, with no intra or extraaxial collection, mass or region of abnormal contrast enhancement.