Hypoxic-ischemic damage in adults, also known as global hypoxic-ischemic injury, is seen in a number of settings and often has devastating neurological sequelae. The most characteristic example is produced by cardiac arrest, like in this case. 

Irreversible brain injury occurs when systemic blood pressure drops below the minimal levels required for sustaining effective brain metabolism, such on the case of 40 minutes of cardiopulmonary resuscitation. Critically severe reductions on brain metabolism cause irreversible disruption of cellular membranes and cell death and is responsible of the finds saw on MRI sequences.