The coexistence of PRES and restricted diffusion in the splenium of corpus callosum highlights the potential possibility of vasoconstriction of the pericollasal branches supplying the splenium arising from the posterior cerebral artery.

Unfortunately, no follow-up imaging was performed to document if these changes were transient, but reversible splenial lesion has been reported to be associated with a wide range of etiologies, however is extremely rare in the setting of PRES.