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Adamantinomatous craniopharyngioma

Case contributed by Frank Gaillard
Diagnosis certain

Patient Data

Age: Adult
Gender: Male

Note: This case has been tagged as "legacy" as it no longer meets image preparation and/or other case publication guidelines.

CT brain

ct

Suprasellar mass, predominantly of intermediate to fluid attenuation without convincing calcification.

MRI pituitary

mri

Selected sagittal and coronal pre and post contrast images demonstrate a multicystic/solid mass in the suprasellar region, with intrinsic high T1 signal. 

Case Discussion

The patient went on to have a resection.

Histology:

The section shows a single small fragment of tissue. This is composed of irregularly shaped islands of mature squamous epithelium which are dispersed in a loose fibrous stroma. These show strong immunostaining for cytokeratins AE1/AE3 and CAM5.2. The stroma contains aggregates of keratin. Focal foreign-body type granulomatous inflammation in association with some collections of keratin are noted. There is also focal dystrophic calcification. No cyst formation is seen. The features are those of a craniopharyngioma.

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