What is the practical difference between a sarcomatoid renal cell carcinoma (sRCC) and an advanced nonsarcomatoid renal cell carcinoma?
Although they may appear similarly on current imaging techniques, the biology is more dedifferentiated with the sarcomatoid variant and it has a poorer prognosis. The ability to selectively target the biology of sRCC for therapeutic purposes is not currently well developed.
Ultrasound-guided core biopsy (20 gauge) of the periphery of the mass.