HISTOLOGY
MACROSCOPIC DESCRIPTION: A core of pale tan tissue measuring 8mm in length and 1mm in diameter and multiple fragments less than 1mm each measuring in aggregate 3 x 2 x 1mm.
MICROSCOPIC DESCRIPTION: Sections of lung biopsy shows alveolar spaces containing multiple rounded/ovoid to slightly irregular shaped yeast-like forms. They are of variable size and there appears to be a capsule. No obvious inflammatory reaction is noted. No granulomas and no acid fast bacilli are noted. No evidence of malignancy is identified.
DIAGNOSIS: Lung biopsy : Fungal elements seen. Appearance raises suggestion of Cryptoccoccus. Please correlate with microbiology.
Microbiology
Specimen site Left lung biopsy
Microscopy Fungal elements seen
Gram Stain ++ Polymorphs, No organisms seen
Culture + Cryptococcus neoformans