Gliomatosis cerebri

Discussion:

This patient underwent a brain biopsy that revealed: infiltrating glioma, consistent with gliomatosis cerebri.

Based upon the histologic features noted in the small biopsies, this glioma would only qualify as an astrocytoma grade II/IV using the Dumas-Duport grading system. Because of the diffuse pattern of infiltration, and sampling, this probably does not accurately reflect the actual grade of this malignant glioma.

Importantly, whereas gliomatosis was previously considered a distinct entity, since the 2016 update to the WHO classification of CNS tumours it is now merely thought of as a growth pattern.

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