Post-transplant lymphoproliferative disorder - sinuses

Discussion:

The patient went on to have a biopsy that confirmed the diagnosis of post-transplant lymphoproliferative disorder.

Histology

The biopsy shows diffuse infiltration by large pleomorphic lymphoid cells which show strong uniform expression of B cell marker CD20.

Final diagnosis:

Post-transplant lymphoproliferative disorder, diffuse large B-cell lymphoma type, EBV negative.

Note: It should be noted that the majority of these tumors in the post-transplant setting are EBV positive.

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