What are the findings on hematoxylin-eosin-stained histopathology slides?
Abnormal clustering and vacuolation of the neuronal cells.
What are the differential diagnoses of MVNT?
Although the appearance is very typical especially on T2WI/FLAIR, differentials include focal cortical dysplasia and dysembryoplastic neuroepithelial tumours.
Are MVNT tumours of malformations?
The precise nature of MVNT is still unknown. It is classified by the World Health Organization Classification of Tumors of the Central Nervous System as a unique cytoarchitectural pattern of gangliocytoma. Given the benign behaviour of these lesions both clinically and on follow-ups, it is most likely to represent a hamartomatous-like lesion rather than a neoplasm. Further research is still necessary to clarify this.
There is a nonenhancing intra-axial T1 hypointense/T2 & FLAIR hyperintense lesion centred on the left parietal operculum in the superficial subcortical and juxtacortical white matter. The lesion consists of groups of several nodules, especially along its internal margin. There is no cortical involvement. There is no diffusion restriction and no mass effect.
The intracranial appearances are otherwise unremarkable.