Bilateral biopsy tracks are again noted in the frontal lobes.
Coronal volumetric scans show atrophy of the hippocampi out of keeping with the changes in the rest of the brain. Multiple small foci of signal dropout on the susceptibility weighted imaging are in keeping with the suspected diagnosis of amyloid angiography. No evidence of superficial siderosis.
Severe abnormality is present in the periventricular and subcortical white matter. No evidence of restricted diffusion or contrast enhancement in these regions. MRA (not shown) remains normal. MR perfusion (not shown) suggests regions of decreased perfusion in the temporoparietal lobes
Conclusion: Overall, features suggest a diagnosis of Alzheimer's disease with associated amyloid angiography