Amputated appendices epiploicae account for the vast majority of free peritoneal bodies (also known as peritoneal loose bodies or peritoneal mice). Other differential diagnoses for peritoneal loose bodies include dropped gallstone, foreign body including surgical clip, fecalith, calcified dermoid, calcified echinococcal cyst, calcified uterine/gastric leiomyoma and spontaneous amputated ovary.  Although dropped surgical clips have been known to be peritoneal loose bodies, the surgical clip granuloma presenting as a peritoneal loose body is quite rare.

Usually, the peritoneal loose bodies are innocuous and not clinically significant. There have been few case reports where peritoneal loose bodies were the etiology of urinary retention, bowel obstruction and chronic abdominal pain. The management of symptomatic loose bodies is usually surgical removal via laparoscopy.