What is the most common pediatric posterior fossa tumor?
Medulloblastoma is the most common malignant central nervous system tumor in children and represent the most common pediatric posterior fossa tumor.
What are the common symptoms and signs of medulloblastoma
Headache, vomiting, and nausea are common symptoms, secondary to hydrocephalus from obstruction of the fourth ventricle. Ataxia, spasticity, papilledema, nystagmus, are common clinical signs.
What are the WHO major histopathological types of medulloblastomas?
The four major histopathological types consist of classic, desmoplastic-nodular, large cell/anaplastic, and extensive nodularity.
What are the genetic types of the WHO classification of medulloblastomas?
The WHO genetic classification divides tumors into four subgroups designated as wingless (WNT), sonic hedgehog (SHH), Group 3, and Group 4.
What are drop-metastases?
Drop-metastases are tumor implants transmitted through CSF along the spine and cauda equine.
How is the current standard treatment for medulloblastoma?
The treatment for medulloblastomas consists of a combination of surgical resection, radiation therapy, and chemotherapy.
Photomicrograph (hematoxylin-eosin)
Histological report after surgical removal: desmoplastic medulloblastoma,