Meningeal hemangiopericytoma (pediatric)


The patient went to have complete resection of the tumor with the histopathological exam/immunohistochemistry study.

  • Microscopy: showing a highly cellular mesenchymal tumoral proliferation with areas of infiltration of the peripheral glial tissue as well as areas of necrosis with a stromal vascular pattern giving a "staghorn" appearance.
  • Immunohistochemestry
    • CD34: positive
    • STAT6: positive
    • GFAP: negative
    • EMA: negative
    • Ki-67: proliferation index around 30% 
  • Conclusion: The immunohistochemistry profile correlated to the microscopic appearances as well as the MRI features (meningeal tumor) are consistent with a meningeal hemangiopericytoma grade III (WHO 2016).

Meningeal hemangiopericytomas are rare tumors of the meninges, actually considered to be aggressive versions of solitary fibrous tumors of the dura, They account for less than 1% of all intracranial tumors with up to 10% being diagnosed in children.

The main differential diagnoses are:


Additional contributor: R. Bouguelaa, MD