Neonatal hypoxic-ischemic encephalopathy

Discussion:

Term newborn delivered by urgent cesarean section due to abruptio placentae. Low Apgar score. Presented with hypoxic-ischemic encephalopathy manifesting as hypotonia, severe metabolic acidosis, hyponatremia and transient tachypnea of newborn (TTN). Underwent 72-hour whole-body cooling. Cerebral function monitoring (CFM) displayed a very low trace. Later, slight brain activity was seen, partly as seizures and partly as burst suppression. Due to convulsions, both clinical and electrical, he received several anticonvulsants which were gradually discontinued. EEG displayed flattening of electrical brain activity without any epileptic activity.

MRI showed severe global cerebral ischemia with edema.

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