Hyperacute lung transplant rejection

Case contributed by Craig Hacking
Diagnosis certain

Presentation

2 hours post lung transplant. Difficulty ventilating patient.

Patient Data

Age: 55 years
Gender: Female

Lines and tubes: ETT, 2x right jugular CVLs, 2x mediastinal drains, bilateral ICCs, IVC ECMO catheter.

Multiple surgical clips and packs.

Diffuse complete whiteout of both lungs with air bronchograms.

Case Discussion

Massive white out of both lungs in the immediate (hours) post-op period following lung transplantation is in keeping with hyperacute transplant rejection. This is a rare complication that is due to the release of preformed recipient antibodies against the allograft which leads to fulminant pulmonary edema. The patient dies 8 hours later. Autopsy confirmed severe pulmonary edema.

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