Primary mediastinal large B-cell lymphoma

Discussion:

The differentials raised to this were of primary lung carcinoma or lymphoma. It is difficult to determine if the lesion is mediastinal or pulmonary, but a mediastinal component is certainly present. Further CT abdomen and pelvis was unremarkable, no evidence of disease elsewhere.

CT-guided core-biopsy was performed: 

Microscopy: The biopsies consist of tissue cores showing focally prominent stromal
fibrosis and a heavy lymphoid infiltrate, as well as relatively small
fragments of normal-appearing pulmonary alveolar tissue. The lymphoid
infiltrate has a vaguely nodular architecture and consists of an admixture of
small lymphocytes, histiocytes, eosinophils, and aggregates of larger cells
with slightly irregular nuclear membranes, vesicular chromatin, prominent
nucleoli and pale cytoplasm. Reed Sternberg cells are not seen. Very focally,
the lymphoid cells infiltrate in the wall of small blood vessels. There is no
necrosis and granulomas are not identified.
Immunohistochemistry has been performed and the large cells show positive
immunostaining for CD20, CD79a and CD30. CD3 and CD5 stain large numbers of
admixed T lymphocytes. CD10 is positive in scattered cells. There is no
staining for EBV-LMP. Cytokeratin (AE1/3) stains small nests and tubular
structures of epithelial cell, possibly thymic remnants.
Conclusion:  Right lung, core biopsies- Atypical B lymphocyte proliferation,
consistent with mediastinal (thymic) large B-cell lymphoma.

Further staging with PET/CT showed abnormal FDG uptake confined to a single large area of lymphoma in the right lung/paratracheal location and some small peri-bronchial lesions.

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